منابع مشابه
CED-4—The Third Horseman of Apoptosis
activating adaptor proteins have been identified. For The remarkable conservation of physiological cell death example, Mort-1/FADD interacts with certain caspases mechanisms from nematodes to humans has allowed via shared death effector domains (DEDs) and RAIDD/ the genetic pathways of programmed cell death deterCRADD interacts with other caspases via shared CARDs mined in Caenorhabditis elegan...
متن کاملCaenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced
BACKGROUND Programmed cell death or apoptosis is a key feature of normal development, tissue homeostasis and disease progression in metazoans. Genetic studies in the nematode C. elegans have identified three key genes involved in apoptosis, ced-3, ced-4 and ced-9. Expression of ced-3 and ced-4 is required for the induction of cell death, whereas expression of ced-9 is necessary to inhibit cell ...
متن کاملInvolvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells.
B-chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of long-lived B lymphocytes that express high levels of Bcl-2. We examined the involvement of CED-3/ICE-like proteases in the apoptosis of B-CLL cells. One of the substrates of these proteases is poly(ADP [adenosine 5'-diphosphate]-ribose) polymerase (PARP). The effect of different factors that induce the apoptosis of B...
متن کاملThe role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells.
The CED-3-related cysteine proteases (CRCPs) have been implicated as mediators of apoptosis, primarily in hematogenous cell systems, but their role in neuronal apoptosis remains unclear. The present study examined the role of two CRCP families-CPP32- and interleukin-1beta converting enzyme (ICE)-like cysteine proteases-in apoptosis of cerebellar granule cells (CGCs) caused by withdrawal of seru...
متن کاملBcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis.
The ICE/CED-3 family of proteases has been implicated in playing a fundamental role in programmed cell death. Bcl-2 protein represses a number of apoptotic death programs, but the biochemical mechanism of its action is not known. We investigated the activation of ICE/CED-3 proteases induced by three apoptotic stimuli (staurosporine, ceramide, and serum withdrawal) in the neuronal cell line GT1-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 1997
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80497-3